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KMID : 1036720180510030201
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Journal of Nutrition and Health
2018 Volume.51 No. 3 p.201 ~ p.207
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Anti-obesity and LDL-cholesterol lowering effects of silkworm hemolymph inC57BL/6N mice fed high fat diet
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Nam You-Ree
Ko Young-Eun
Ly Sun-Yung
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Abstract
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Purpose: Obesity, a worldwide epidemic, is associated with insulin resistance, hyperlipidemia, hypertension, cardiovascular disease, and certain cancers. Many strategies, including natural alternative anti-obesity agents, are used widely to prevent obesity. This study examined the effects of silkworm hemolymph on the weight control of C57BL/6N mice fed with a high-fat diet.
Methods: The mice were divided into five groups: normal group (N), high-fat diet group (HFC), high-fat diet and silkworm hemolymph (at dose of 1 mL/kg BW (HFS-1), 5 mL/kg BW (HFS-5) and 10 mL/kg (HFS-10) for 12 weeks.
Results: After 12 weeks treatment, the administration of silkworm hemolymph decreased the final body weight significantly along with a decrease in the weights of epididymal fat and total fat. The plasma LDL-cholesterol concentration was significantly lower in the HFS-1, HFS-5, and HFS-10 groups than in the HFC group. In addition, the leptin level of the HFS groups was significantly lower than those of the HFC group without a change in the plasma insulin concentration.
Conclusion: These findings suggest that the silkworm hemolymph may have the potential to prevent obesity.
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KEYWORD
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silkworm hemolymph, anti-obesity, LDL-cholesterol lowering effect
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